Richness of human gut microbiome correlates with metabolic markers

被引：3467

作者：

Le Chatelier, Emmanuelle ^{[1
]}

Nielsen, Trine ^{[2
]}

Qin, Junjie ^{[3
]}

Prifti, Edi ^{[1
]}

Hildebrand, Falk ^{[4
,5
]}

Falony, Gwen ^{[4
,5
]}

Almeida, Mathieu ^{[1
]}

Arumugam, Manimozhiyan ^{[2
,3
,6
]}

Batto, Jean-Michel ^{[1
]}

Kennedy, Sean ^{[1
]}

Leonard, Pierre ^{[1
]}

Li, Junhua ^{[3
,7
]}

Burgdorf, Kristoffer ^{[2
]}

Grarup, Niels ^{[2
]}

Jorgensen, Torben ^{[8
,9
,10
]}

Brandslund, Ivan ^{[11
,12
]}

Nielsen, Henrik Bjorn ^{[13
,14
]}

Juncker, Agnieszka S. ^{[13
,14
]}

Bertalan, Marcelo ^{[13
,14
]}

Levenez, Florence ^{[1
]}

Pons, Nicolas ^{[1
]}

Rasmussen, Simon ^{[13
,14
]}

Sunagawa, Shinichi ^{[6
]}

Tap, Julien ^{[1
,6
]}

Tims, Sebastian ^{[15
]}

Zoetendal, Erwin G. ^{[15
]}

Brunak, Soren ^{[13
,14
]}

Clement, Karine ^{[16
,17
,18
]}

Dore, Joel ^{[1
,19
]}

Kleerebezem, Michiel ^{[15
]}

Kristiansen, Karsten ^{[20
]}

Renault, Pierre ^{[19
]}

Sicheritz-Ponten, Thomas ^{[13
,14
]}

de Vos, Willem M. ^{[15
,21
]}

Zucker, Jean-Daniel ^{[17
,22
]}

Raes, Jeroen ^{[4
,5
]}

Hansen, Torben ^{[2
,23
]}

Bork, Peer ^{[6
]}

Wang, Jun ^{[24
,25
,26
]}

Ehrlich, S. Dusko

Pedersen, Oluf ^{[2
,27
,28
,29
]}

机构：

[1] INRA, Metagenopolis US1367, F-78350 Jouy En Josas, France

[2] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark

[3] BGI Shenzhen, Shenzhen 518083, Peoples R China

[4] VIB, Dept Biol Struct, B-1050 Brussels, Belgium

[5] Vrije Univ Brussel, Dept Biosci Engn, B-1050 Brussels, Belgium

[6] European Mol Biol Lab, D-69117 Heidelberg, Germany

[7] S China Univ Technol, Sch Biosci & Biotechnol, Guangzhou 510006, Guangdong, Peoples R China

[8] Glostrup Univ Hosp, Res Ctr Prevent & Hlth, DK-2900 Glostrup, Denmark

[9] Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark

[10] Aalborg Univ, Fac Med, Inst Publ Hlth, DK-9100 Aalborg, Denmark

[11] Vejle Hosp, Dept Clin Biochem, DK-7100 Vejle, Denmark

[12] Univ Southern Denmark, Inst Reg Hlth Res, DK-8200 Odense, Denmark

[13] Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark

[14] Tech Univ Denmark, Novo Nordisk Fdn, Ctr Biosustainabil, DK-2800 Lyngby, Denmark

[15] Wageningen Univ, Lab Microbiol, NL-6710 BA Ede, Netherlands

[16] Ctr Rech Cordeliers, Inst Natl Sante & Rech Med, U872, Equipe 7, F-75006 Paris, France

[17] Univ Paris 06, F-75006 Paris, France

[18] CRNH Ile France, Inst Cardiometab & Nutr, AP HP, F-75013 Paris, France

[19] INRA, MICALIS, UMR14121, F-78350 Jouy En Josas, France

[20] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[21] Univ Helsinki, Dept Bacteriol & Immunol, FIN-00014 Helsinki, Finland

[22] Inst Rech Dev, UMI 209, Unite Modelisat Math & Informat Syst Complexes, F-93143 Bondy, France

[23] Univ Southern Denmark, Fac Hlth Sci, DK-8200 Odense, Denmark

[24] King Abdulaziz Univ, Jeddah 21589, Saudi Arabia

[25] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark

[26] Aarhus Univ, Ctr Sequencing, DK-8000 Aarhus C, Denmark

[27] Hagedorn Res Inst, DK-2820 Gentofte, Denmark

[28] Univ Copenhagen, Fac Hlth & Med Sci, Inst Biomed Sci, DK-2200 Copenhagen, Denmark

[29] Aarhus Univ, Fac Hlth, DK-8000 Aarhus, Denmark

来源：

NATURE | 2013年 / 500卷 / 7464期

关键词：

BODY-MASS INDEX; DIET-INDUCED OBESITY; WIDE ASSOCIATION; WEIGHT; INFLAMMATION; LOCI; RESISTANCE; CHILDHOOD; VARIANTS; BACTERIA;

D O I：

10.1038/nature12506

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.

引用

页码：541 / +

页数：9

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