Increase of angiotensin-converting enzyme activity and peripheral sympathetic dysfunction could contribute to hypertension development in streptozotocin-induced diabetic rats

被引：31

作者：

Musial, Diego C. ^{[1
]}

da Silva Junior, Edilson D. ^{[1
]}

da Silva, Regiane M. ^{[1
]}

Miranda-Ferreira, Regiane ^{[1
]}

Lima-Landman, M. Teresa R. ^{[1
]}

Jurkiewicz, Aron ^{[1
]}

Garcia, Antonio G. ^{[2
,3
,4
]}

Jurkiewicz, Neide H. ^{[1
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Dept Pharmacol, BR-04044020 Sao Paulo, Brazil

[2] Univ Autonoma Madrid, Fac Med, Inst Teofilo Hernando, Madrid, Spain

[3] Univ Autonoma Madrid, Fac Med, Dept Farmacol, Madrid, Spain

[4] Hosp Univ La Princesa, Serv Farmacol Clin, Inst Invest Sanitaria, Madrid, Spain

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2013年 / 10卷 / 06期

关键词：

Diabetes; hypertension; angiotensin-converting enzyme; sympathetic dysfunction; ISOLATED VAS-DEFERENS; PURINERGIC NEUROTRANSMISSION; BLOOD-PRESSURE; SMOOTH-MUSCLE; NOREPINEPHRINE; RELEASE; SYSTEM; KINASE; CELLS; ACE;

D O I：

10.1177/1479164113496441

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetes augments the risk of hypertension. Although several factors have been implicated in the development of such hypertensive state, we designed this study to investigate blood pressure development, the activity of angiotensin-converting enzyme (ACE) in blood as well as sympathetic neurotransmission in the vas deferens of diabetic rats. We used streptozotocin (STZ)-induced diabetic rats (60 mg/kg) in order to evaluate the systolic blood pressure (SBP), ACE activity and peripheral sympathetic neurotransmission. We observed the following changes of parameters: increase of SBP, decrease of heart rate, augmentation of plasma ACE activity, enhancement of phasic and tonic vas deferens contractions elicited by electrical stimulation at 5 Hz, increase of maximal response to noradrenaline (NA) and decrease of adenosine triphosphate (ATP)-elicited contraction of vasa deferentia. The results reveal that in the development of hypertension in diabetic rats, augmentation of circulating ACE activity precedes the sympathetic dysfunction. Additionally, it seems that the purinergic and noradrenergic neurotransmission is compromised.

引用

页码：498 / 504

页数：7

共 30 条

[1]

Anwer Z, 2011, EUR REV MED PHARMACO, V15, P1256

[2]

Purinergic cotransmission [J].

Burnstock, G .

BRAIN RESEARCH BULLETIN, 1999, 50 (5-6) :355-357

[3]

EFFECT OF DIABETES AND FASTING ON GLUT-4 (MUSCLE FAT) GLUCOSE-TRANSPORTER EXPRESSION IN INSULIN-SENSITIVE TISSUES - HETEROGENEOUS RESPONSE IN HEART, RED AND WHITE MUSCLE [J].

CAMPS, M ;

CASTELLO, A ;

MUNOZ, P ;

MONFAR, M ;

TESTAR, X ;

PALACIN, M ;

ZORZANO, A .

BIOCHEMICAL JOURNAL, 1992, 282 :765-772

[4]

Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens [J].

Caricati-Neto, A ;

D'angelo, LCA ;

Reuter, H ;

Jurkiewicz, NH ;

Garcia, AG ;

Jurkiewicz, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 503 (1-3) :191-201

[5]

Diabetes and Hypertension: Is There a Common Metabolic Pathway? [J].

Cheung, Bernard M. Y. ;

Li, Chao .

CURRENT ATHEROSCLEROSIS REPORTS, 2012, 14 (02) :160-166

[6]

Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus [J].

Conceiçao, IM ;

Jurkiewicz, A ;

Fonseca, DR ;

Opperman, AR ;

Freitas, TA ;

Lebrun, I ;

Garcez-do-Carmo, L .

BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (04) :519-527

[7]

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin [J].

Elsner, M ;

Guldbakke, B ;

Tiedge, M ;

Munday, R ;

Lenzen, S .

DIABETOLOGIA, 2000, 43 (12) :1528-1533

[8]

LPS activates ADAM9 dependent shedding of ACE from endothelial cells [J].

English, William R. ;

Corvol, Pierre ;

Murphy, Gillian .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 421 (01) :70-75

[9]

Differential Responses to Blood Pressure and Oxidative Stress in Streptozotocin-Induced Diabetic Wistar-Kyoto Rats and Spontaneously Hypertensive Rats: Effects of Antioxidant (Honey) Treatment [J].

Erejuwa, Omotayo O. ;

Sulaiman, Siti A. ;

Ab Wahab, Mohd Suhaimi ;

Sirajudeen, Kuttulebbai N. S. ;

Salleh, Md Salzihan Md ;

Gurtu, Sunil .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (03) :1888-1907

[10]

Grossman E, 2008, ADV CARDIOL, V45, P82, DOI 10.1159/000115189

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