Effects of acute restraint stress on endogenous adrenomedullin levels

被引：26

作者：

Khan, S

Michaud, D

Moody, TW

Anisman, H

Merali, Z

机构：

[1] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada

[3] NCI, Rockville, MD USA

[4] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada

来源：

NEUROREPORT | 1999年 / 10卷 / 13期

关键词：

adrenomedullin; ACTH; homeostasis; HPA axis; restraint stress;

D O I：

10.1097/00001756-199909090-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ADRENOMEDULLIN (ADM) is a 52 amino acid peptide, with a potent hypotensive/vasodilatory action. Levels of ADM are significantly elevated in patients with hypertension, and it has been postulated that such stressor-related increases may serve a regulatory or protective function. The current study assessed the effects of acute restraint stress on ADM levels in regions of the brain, plasma and peripheral tissue including heart, lung and the adrenal glands of rats. This stressor, known to stimulate sympathetic activity as well as the hypothalamic-pituitary adrenal (HPA) axis, produced a significant increase in ADM levels in the pituitary gland, plasma and adrenal glands, all of which are key components of the HPA axis. The results suggest a regulatory and/or protective role for ADM in countering HPA activation following a variety of physiological and psychological stressors. (C) 1999 Lippincott Williams & Wilkins.

引用

收藏

页码：2829 / 2833

页数：5

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