Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

被引：211

作者：

Cohen, Dara Hope ^{[1
]}

LeRoith, Derek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Samuel Bronfman Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA

来源：

关键词：

GROWTH-FACTOR-I; HUMAN-BREAST-CANCER; MONOCLONAL-ANTIBODY CP-751,871; MAMMARY-TUMOR DEVELOPMENT; HUMAN LEPTIN GENE; PLASMA C-PEPTIDE; BODY-MASS INDEX; PROSTATE-CANCER; COLORECTAL-CANCER; RECEPTOR ISOFORM;

D O I：

10.1530/ERC-11-0374

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metformin and exogenous insulin, used to treat T2D may affect the risk of cancer and cancer-related mortality. Newer therapies targeting the insulin and IGF1 systems are being developed for use in cancer therapy. Endocrine-Related Cancer (2012) 19 F27-F45

引用

页码：F27 / F45

页数：19

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