'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach

被引：322

作者：

Hu, Che-Ming J. ^{[1
,2
]}

Fang, Ronnie H. ^{[1
,2
]}

Luk, Brian T. ^{[2
,3
]}

Chen, Kevin N. H. ^{[1
]}

Carpenter, Cody ^{[1
]}

Gao, Weiwei ^{[1
,2
]}

Zhang, Kang ^{[1
,4
,5
,6
]}

Zhang, Liangfang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Shiley Eye Ctr, La Jolla, CA 92093 USA

[6] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China

来源：

NANOSCALE | 2013年 / 5卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

BIOMIMETIC DELIVERY; CD47; PHAGOCYTOSIS; ACTIVATION; NANOPARTICLES; SURFACES; CARRIERS; CELLS;

D O I：

10.1039/c3nr00015j

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.

引用

页码：2664 / 2668

页数：5

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