Intravenous immunoglobulin for resistant Clostridium difficile infection

被引:23
作者
Murphy, C [1 ]
Vernon, M [1 ]
Cullen, M [1 ]
机构
[1] Wythenshawe Hosp, Dept Geriatr Med, Manchester M23 9LT, Lancs, England
关键词
Clostridium difficile; diarrhoea; immunoglobulin; elderly;
D O I
10.1093/ageing/afi212
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Clostridium difficile (CD)-associated diarrhoea and colitis may relapse in up to 20% of treated patients. We present a patient who failed to respond over a 6-month period to treatment either singly or in combination with metronidazole, vancomycin, rifampicin, cholestyramine and probiotics. Her diarrhoea rapidly resolved after a 3-day course of intravenous immunoglobulin. This treatment may compensate for a failed immune response to CD toxin and should be considered for relapsing CD-associated diarrhoea where there is no response to conventional treatment strategies.
引用
收藏
页码:85 / 86
页数:2
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