Quality control of gene expression in the nucleus

被引：6

作者：

Custódio, N ^{[1
]}

Carmo-Fonseca, M ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Hist & Embryol, Lisbon, Portugal

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2001年 / 5卷 / 03期

关键词：

RNA processing; RNA transport; RNA polymerase II; nonsense-mediated decay; nuclear organisation;

D O I：

10.1111/j.1582-4934.2001.tb00160.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteins are responsible for most cellular and extra-cellular functions. If altered, proteins can loose their normal activity and/or gain new properties. Either way the consequences may be deleterious for the cell and lead to disease at the organism level. Not surprisingly, eukaryotes have evolved mechanisms to recognize abnormal messenger RNAs and prevent them from producing faulty proteins. Protein-encoding genes are transcribed in the nucleus by RNA polymerase II as precursor RNAs that undergo extensive processing before being translocated to the cytoplasm for translation by the ribosomes. This spatial and temporal separation between RNA and protein synthesis offers an immense opportunity for control and regulation. Here we review recent studies that are beginning to unravel how the coupling between transcription, processing and transport of mRNAs contributes to control the quality of gene expression in the nucleus.

引用

页码：267 / 275

页数：9

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