Blood Serum Levels of IL-2, IL-6, IL-8, TNF-α and IL-1β in Patients on Maintenance Hemodialysis

被引：22

作者：

Rysz, Jacek ^{[1
]}

Banach, Maciej ^{[2
]}

Cialkowska-Rysz, Aleksandra ^{[3
]}

Stolarek, Robert ^{[1
]}

Barylski, Marcin ^{[4
]}

Drozdz, Jaroslaw ^{[5
]}

Okonski, Piotr ^{[2
]}

机构：

[1] Med Univ Lodz, Univ Hosp Lodz 2, Dept Family Med 2, PL-91425 Lodz, Poland

[2] Med Univ Lodz, Univ Hosp Lodz 3, Dept Cardiac Surg, PL-91425 Lodz, Poland

[3] Med Univ Lodz, Dept Oncol, PL-91425 Lodz, Poland

[4] Med Univ Lodz, Boleslaw Szarecki Univ Hosp 5, Dept Internal Dis & Cardiol Rehabil, PL-91425 Lodz, Poland

[5] Med Univ Lodz, Bieganski Hosp, Dept Cardiol 2, PL-91425 Lodz, Poland

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2006年 / 3卷 / 02期

关键词：

cytokine; chronic renal failure; hemodialysis;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Cytokines are essential mediators of immune response and inflammatory reactions. Patients with chronic renal failure (CRF) commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins in addition to bioincompatibility of dialyzer membranes. During a hemodialysis (HD) session, cytokines are released mainly by monocytes activated by endotoxin-type compounds in dialyzer fluid, complement factors and direct contact with dialyzer membrane. The study included 15 CRF patients, aged 36.4 +/- 2.9 years, on regular HD maintenance therapy for mean 68 +/- 10 months and 15 healthy controls. It was designed to assess serum levels of a panel of inflammatory cytokines: IL-1 beta, IL-2, IL-6, IL-8 and TNF-alpha in CRF patients on regular maintenance HD before, 20, 60 and 240 minutes of a single HD session in parallel with C-reactive protein (CRP) as an additional parameter. CRP concentration was increased in HD patients when compared with healthy controls. The concentrations of IL-1, IL-6, IL-8 and TNF-alpha were increased, whereas the serum level of IL-2 was not altered during a single HD session.

引用

页码：151 / 154

页数：4

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