HIV infection: where have all the T cells gone?

被引:23
作者
Rowland-Jones, S [1 ]
机构
[1] John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
关键词
D O I
10.1016/S0140-6736(99)90017-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
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页码:5 / 7
页数:3
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共 17 条
[1]   Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease [J].
Autran, B ;
Carcelain, G ;
Li, TS ;
Blanc, C ;
Mathez, D ;
Tubiana, R ;
Katlama, C ;
Debre, P ;
Leibowitch, J .
SCIENCE, 1997, 277 (5322) :112-116
[2]   DETECTION OF 3 DISTINCT PATTERNS OF T-HELPER CELL DYSFUNCTION IN ASYMPTOMATIC, HUMAN IMMUNODEFICIENCY VIRUS-SEROPOSITIVE PATIENTS - INDEPENDENCE OF CD4+ CELL NUMBERS AND CLINICAL STAGING [J].
CLERICI, M ;
STOCKS, NI ;
ZAJAC, RA ;
BOSWELL, RN ;
LUCEY, DR ;
VIA, CS ;
SHEARER, GM .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) :1892-1899
[3]   HIV infection induces changes in CD4(+) T-cell phenotype and depletions within the CD4(+) T-cell repertoire that are not immediately restored by antiviral or immune-based therapies [J].
Connors, M ;
Kovacs, JA ;
Krevat, S ;
GeaBanacloche, JC ;
Sneller, MC ;
Flanigan, M ;
Metcalf, JA ;
Walker, RE ;
Falloon, J ;
Baseler, M ;
Stevens, R ;
Feuerstein, I ;
Masur, H ;
Lane, HC .
NATURE MEDICINE, 1997, 3 (05) :533-540
[4]   Changes in thymic function with age and during the treatment of HIV infection [J].
Douek, DC ;
McFarland, RD ;
Keiser, PH ;
Gage, EA ;
Massey, JM ;
Haynes, BF ;
Polis, MA ;
Haase, AT ;
Feinberg, MB ;
Sullivan, JL ;
Jamieson, BD ;
Zack, JA ;
Picker, LJ ;
Koup, RA .
NATURE, 1998, 396 (6712) :690-695
[5]   Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy [J].
Gorochov, G ;
Neumann, AU ;
Kereveur, A ;
Parizot, C ;
Li, TS ;
Katlama, C ;
Karmochkine, M ;
Raguin, G ;
Autran, B ;
Debré, P .
NATURE MEDICINE, 1998, 4 (02) :215-221
[6]   Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection (vol 103, pg 453, 1999) [J].
Haynes, BF ;
Hale, LP ;
Weinhold, KJ ;
Patel, DD ;
Liao, HX ;
Bressler, PB ;
Jones, DM ;
Demarest, JF ;
Gebhard-Mitchell, K ;
Haase, AT ;
Bartlett, JA .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :921-921
[7]   Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans [J].
Hellerstein, M ;
Hanley, MB ;
Cesar, D ;
Siler, S ;
Papageorgopoulos, C ;
Wieder, E ;
Schmidt, D ;
Hoh, R ;
Neese, R ;
Macallan, D ;
Deeks, S ;
McCune, JM .
NATURE MEDICINE, 1999, 5 (01) :83-89
[8]   RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].
HO, DD ;
NEUMANN, AU ;
PERELSON, AS ;
CHEN, W ;
LEONARD, JM ;
MARKOWITZ, M .
NATURE, 1995, 373 (6510) :123-126
[9]   The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses [J].
Kalams, SA ;
Walker, BD .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2199-2204
[10]   Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease [J].
Li, TS ;
Tubiana, R ;
Katlama, C ;
Calvez, V ;
Ait Mohand, H ;
Autran, B .
LANCET, 1998, 351 (9117) :1682-1686