Chitosan membrane as a template for hydroxyapatite crystal growth in a model dual membrane diffusion system

被引：60

作者：

Ehrlich, H

Krajewska, B

Hanke, T

Born, R

Heinemann, S

Knieb, C

Worch, H

机构：

[1] Tech Univ Dresden, Inst Mat Sci, Max Bergmann Ctr Biomat, D-01069 Dresden, Germany

[2] Jagiellonian Univ, Fac Chem, PL-30060 Krakow, Poland

来源：

JOURNAL OF MEMBRANE SCIENCE | 2006年 / 273卷 / 1-2期

关键词：

gel chitosan membranes; hydroxyapatite; dual membrane diffusion system; biomineralization; bone tissue repair and regeneration;

D O I：

10.1016/j.memsci.2005.11.050

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Being a biocompatible, biodegradable and bioactive material, chitosan in the form of membranes offers a great potential as a substrate in mineralization processes in vitro. In the present work, the crystal growth of calcium phosphate phases on gel chitosan membranes was studied in the dual membrane diffusion system. In the system cation- and anion-selective membranes are used to control Ca2+ and PO43- ionic diffusion to generate supersaturation reaction conditions. We show for the first time that the system can be successfully used for oriented crystal growth and for qualitative control of calcium phosphate phases on chitosan matrices in a biomimetic mode. The mineralized chitosan can be potentially applied in bone tissue repair and regeneration. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：124 / 128

页数：5

共 29 条

[1]

Beppu Marisa M., 2002, Mat. Res., V5, P47, DOI 10.1590/S1516-14392002000100008

[2] PAA influence on chitosan membrane calcification [J].