Amygdala or ventral hippocampal lesions at two early stages of life differentially affect open field behaviour later in life; an animal model of neurodevelopmental psychopathological disorders

被引：42

作者：

Daenen, EWPM ^{[1
]}

Wolterink, G ^{[1
]}

Gerrits, MAFM ^{[1
]}

Van Ree, JM ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Dept Pharmacol, Div Pharmacol & Anat,Rudolf Magnus Inst Neurosci, NL-3508 AB Utrecht, Netherlands

来源：

BEHAVIOURAL BRAIN RESEARCH | 2002年 / 131卷 / 1-2期

关键词：

amygdala; hippocampus; neonatal lesions rat; locomotor activity; animal model; neurodevelopmental disorder; schizophrenia;

D O I：

10.1016/S0166-4328(01)00350-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Psychiatric disorders like schizophrenia or autism are thought to result from disruption of the normal pattern of brain development. Abnormalities in the amygdaloid complex and hippocampus have been reported in these disorders. In the present study rats were lesioned in the amygdala or ventral hippocampus on day 7 of life (immature brain) or day 21 of life (almost mature brain) and open field behaviour was determined later in life before and after puberty. Lesioning on day 7 resulted in behavioural changes, interpreted as locomotor stereotypy and decreased anxiety in case of amygdala or hippocampus, respectively. These effects were more profoundly present after puberty. Lesioning on day 21 did not result in these behavioural changes, which subscribes to the importance of the stage of brain maturation on functional development. The results suggest that the behavioural changes in rats lesioned on day 7 may due to a malfunctioning of structures connected to the amygdala or ventral hippocampus. Brain lesions made on day 7 of life may serve as a potential model of psychopathological neurodevelopmental disorders. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：67 / 78

页数：12

共 45 条

[1] MEDIAL TEMPORAL LOPE STRUCTURES AND AUTISM - A REVIEW OF CLINICAL AND EXPERIMENTAL FINDINGS [J].