Detection of Isolated Cerebrovascular β-Amyloid with Pittsburgh Compound B

被引：79

作者：

Greenberg, Steven M. ^{[1
]}

Grabowski, Thomas ^{[2
,3
]}

Gurol, M. Edip ^{[2
]}

Skehan, Maureen E. ^{[1
]}

Nandigam, R. N. Kaveer ^{[1
]}

Becker, John A. ^{[4
]}

Garcia-Alloza, Monica ^{[1
]}

Prada, Claudia ^{[1
]}

Frosch, Matthew P. ^{[5
]}

Rosand, Jonathan ^{[1
]}

Viswanathan, Anand ^{[1
]}

Smith, Eric E. ^{[1
]}

Johnson, Keith A. ^{[1
,4
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA 02114 USA

[2] Univ Iowa, Coll Med, Dept Neurol, Iowa City, IA 52242 USA

[3] Univ Iowa, Coll Med, Dept Radiol, Iowa City, IA 52242 USA

[4] Harvard Univ, Dept Radiol, Sch Med, Boston, MA 02114 USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA 02114 USA

来源：

ANNALS OF NEUROLOGY | 2008年 / 64卷 / 05期

关键词：

D O I：

10.1002/ana.21528

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Imaging of cerebrovascular beta-amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42-year-old man with early manifestations of Iowa-type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar P-amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions.

引用

页码：587 / 591

页数：5

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