Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats

被引:65
作者
Prakash, Atish [1 ,2 ]
Shur, Bhargabi [3 ]
Kumar, Anil [2 ]
机构
[1] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3010, Australia
[2] Panjab Univ, UGC Ctr Adv Study, Univ Inst Pharmaceut Sci, Pharmacol Div, Chandigarh 160014, India
[3] Sambalpur Univ, Dept Environm Sci, Environm Sci & Engn Div, Jyoti Vihar, Sambalpur, India
关键词
Aluminum; oxidative stress; naringin; neuroprotection; memory impairment; GRAPEFRUIT FLAVANONE; ALZHEIMERS-DISEASE; IN-VIVO; BRAIN; DYSFUNCTION; MECHANISMS; TOXICITY; NEURONS; PLASMA; MICE;
D O I
10.3109/00207454.2013.785542
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Aluminum has been indicated in neurodegenerative disorders and naringin, a bioflavonoid has been used to reduce neurotoxic effects of aluminum against aluminum chloride-induced rats. Therefore, present study has been designed to explore the possible role of naringin against aluminum-induced cognitive dysfunction and oxidative damage in rats. Aluminum (100 mg/kg) and naringin (40 and 80 mg/kg) drug treatment were administered orally for six weeks to male wistar rats. Various behavioral performance tasks, biochemical, mitochondrial oxidative parameters, and aluminum concentration in the brain were assessed. Aluminum chloride treatment significantly caused cognitive dysfunction and mitochondria oxidative damage as compared to vehicle treated control group. Besides, aluminum chloride treatment significantly increased acetyl cholinesterase activity and aluminum concentration in the brain as compared to sham. Chronic administration of naringin significantly improved cognitive performance and attenuated mitochondria oxidative damage, acetyl cholinesterase activity, and aluminum concentration in aluminum-treated rats as compared to control rats. Results of the study demonstrate neuroprotective potential of naringin against aluminum chloride-induced cognitive dysfunction and mitochondrial oxidative damage.
引用
收藏
页码:636 / 645
页数:10
相关论文
共 48 条
[1]
Blaylock RL, 2011, J MED FOOD, V1, P46
[2]
NEUROCOGNITIVE EFFECTS OF ALUMINUM [J].
BOLLA, KI ;
BRIEFEL, G ;
SPECTOR, D ;
SCHWARTZ, BS ;
WIELER, L ;
HERRON, J ;
GIMENEZ, L .
ARCHIVES OF NEUROLOGY, 1992, 49 (10) :1021-1026
[3]
The neurotoxicity of environmental aluminum is still an issue [J].
Bondy, Stephen C. .
NEUROTOXICOLOGY, 2010, 31 (05) :575-581
[4]
Differential toxicity of aluminum salts in human cell lines of neural origin: Implications for neurodegeneration [J].
Campbell, A ;
Hamai, D ;
Bondy, SC .
NEUROTOXICOLOGY, 2001, 22 (01) :63-71
[5]
Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo:: molecular mechanisms and implications for neuropathology [J].
Canales, JJ ;
Corbalán, R ;
Montoliu, C ;
Llansola, M ;
Monfort, P ;
Erceg, S ;
Hernandez-Viadel, M ;
Felipo, V .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 87 (1-2) :63-69
[6]
Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits [J].
Choe, SC ;
Kim, HS ;
Jeong, TS ;
Bok, SH ;
Park, YB .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2001, 38 (06) :947-955
[7]
Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits [J].
Choi, Soo-Youn ;
Ko, Hee-Chul ;
Ko, Soo-Youn ;
Hwang, Joon-Ho ;
Park, Ji-Gweon ;
Kang, Shin-Hae ;
Han, Sang-Hun ;
Yun, Su-Hyun ;
Kim, Se-Jae .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (04) :772-778
[8]
TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[9]
A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[10]
Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK [J].
Exley, C. ;
Esiri, M. M. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (07) :877-879