The first asymmetric synthesis of a dopamine D1 agonist, dihydrexidine, employing asymmetric conjugate addition technology

被引：29

作者：

Asano, Y ^{[1
]}

Yamashita, M ^{[1
]}

Nagai, K ^{[1
]}

Kuriyama, M ^{[1
]}

Yamada, K ^{[1
]}

Tomioka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(01)01823-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric synthesis of benzophenanthridine dopamine D1 full agonist, dihydrexidine, was accomplished employing three key processes, external chiral ligand-cont rolled conjugate addition of phenyllithium, Curtius conversion of a carboxylic group to an amino group, and finally Pictet-Spengler type cyclization completing skeleton construction. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8493 / 8495

页数：3

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