Solid-phase synthesis of bis-cyclic guanidines from tripeptides

被引：20

作者：

Acharya, AN ^{[1
]}

Ostresh, JM ^{[1
]}

Houghten, RA ^{[1
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

来源：

TETRAHEDRON | 2001年 / 57卷 / 50期

关键词：

combinatorial synthesis; solid-phase synthesis; cyclic guanidine;

D O I：

10.1016/S0040-4020(01)01010-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the solid-phase synthesis of bis-cyclic guanidines from reduced tripeptides is described. The exhaustive reduction of the tripeptides generated tetra-amines that on treatment with cyanogen bromide, afforded bis-cyclic guanidines having three separate variable positions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9911 / 9914

页数：4

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