Circadian topology of metabolism

被引：498

作者：

Bass, Joseph ^{[1
,2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Neurobiol, Weinberg Coll Arts & Sci, Evanston, IL 60208 USA

来源：

NATURE | 2012年 / 491卷 / 7424期

关键词：

REV-ERB-ALPHA; HYPOCRETIN OREXIN; MAMMALIAN CLOCK; BLOOD-PRESSURE; TRANSCRIPTION; RECEPTOR; RHYTHMS; MELANOPSIN; EXPRESSION; BEHAVIOR;

D O I：

10.1038/nature11704

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.

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收藏

页码：348 / 356

页数：9

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