Molecular epidemiology of enterovirus 71 over two decades in an Australian urban community

被引：91

作者：

Sanders, SA

Herrero, LJ

McPhie, K

Chow, SSW

Craig, ME

Dwyer, DE

Rawlinson, W

McMinn, PC

机构：

[1] Telethon Inst Child Hlth Res, Div Virol, Subiaco, WA, Australia

[2] Univ Western Australia, Dept Microbiol, Nedlands, WA 6009, Australia

[3] Princess Margaret Hosp Children, Dept Microbiol, Subiaco, WA, Australia

[4] Prince Wales Hosp, SEALS Microbiol, Div Virol, Sydney, NSW, Australia

[5] Westmead Hosp, ICPMR, CIDMLS, Sydney, NSW, Australia

[6] Univ New S Wales, Sch Med Sci, Sydney, NSW 2036, Australia

[7] Univ New S Wales, Sch Womens & Childrens Hlth, Sydney, NSW 2036, Australia

[8] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2036, Australia

来源：

ARCHIVES OF VIROLOGY | 2006年 / 151卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1007/s00705-005-0684-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterovirus 71 (EV71), first isolated in 1969, has been responsible for numerous outbreaks of hand, foot and mouth disease (HFMD) with a small proportion of cases associated with neurological disease. Since 1997 there has been a significant increase in both the prevalence and virulence of EV71 in the Asia-Pacific region. We have examined the genetic diversity of EV71 in a large Australian city (Sydney N.S.W.) over a nineteen-year period. We determined the VP1 gene sequence of forty-eight EV71 strains isolated between 1983 and 2001. Analysis by molecular phylogeny revealed the presence of four subgenogroups B2, B4, C1 and C2. The results indicate that the major lineage circulating in Sydney N.S.W. was subgenogroup C1 with a recent switch in dominance to B4 in 2000 and 2001.

引用

页码：1003 / 1013

页数：11

共 20 条

[1] Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998 [J].