Bullfrog retinal bipolar cells may express heterogeneous glycine receptors at dendrites and axon terminals

被引：7

作者：

Du, JL

Yang, XL

机构：

[1] Fudan Univ, Inst Neurobiol, Shanghai 200433, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2002年 / 322卷 / 03期

基金：

中国国家自然科学基金;

关键词：

bullfrog; retinal bipolar cell; whole-cell recording; glycine receptor; non-stationary noise analysis; single-channel conductance;

D O I：

10.1016/S0304-3940(01)02523-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Subcellular localization and properties of glycine receptors on bipolar cells (BCs) were studied using whole-cell recordings and non-stationary noise analysis (NSNA) in bullfrog retinal slices. The currents elicited by focally applied glycine were of comparable amplitudes at the dendrites and axon terminals of both OFF and ON BCs. Moreover, glycine receptors were also expressed at the axons of some BCs. NSNA revealed that the weighted mean single-channel conductance of the glycine receptors at the dendrites (18.2 pS) was significantly larger than that of those at the axon terminals (8.1 pS), thus implying that the glycine receptors on bullfrog retinal BCs may be heterogeneous at these two sites. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：177 / 181

页数：5

共 17 条

[1]

RELAXATION AND FLUCTUATIONS OF MEMBRANE CURRENTS THAT FLOW THROUGH DRUG-OPERATED CHANNELS [J].