Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides

被引：15

作者：

Zhang, JX

Woods, RJ

Brown, PB

Lee, KD

Kane, RR ^{[1
]}

机构：

[1] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

[2] Baylor Univ, Ctr Drug Discovery, Waco, TX 76798 USA

[3] Dongguk Univ, Dept Chem, Kyong Ju, Kyungbuk 780350, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(02)00050-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to determine which constituents of the mixture were responsible for the observed tissue bonding and to facilitate study of the mechanism, we have synthesized each of the primary constituents of the mixture. Each naphthalimide synthesized has been demonstrated to photochemically crosslink proteins. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：853 / 856

页数：4

共 16 条

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