Vicarious silylative mukaiyama aldol reaction: A vinylogous extension

被引：36

作者：

Curti, Claudio ^{[1
]}

Sartori, Andrea ^{[1
]}

Battistini, Lucia ^{[1
]}

Rassu, Gloria ^{[2
]}

Buffeddu, Paola ^{[2
]}

Zanardi, Franca ^{[1
]}

Casiraghi, Giovanni ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Farmaceut, I-43100 Parma, Italy

[2] CNR, Ist Chim Biomol, I-07040 Sassari, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 14期

关键词：

D O I：

10.1021/jo800741c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A vinylogous, silylative, and direct variant of the venerable Mukaiyama aldol reaction has been developed. Exploiting N-Boc-pyrrol-2(5H)-one as the conjugate donor, several aldehyde and ketone acceptors were scrutinized under the guidance of suitable dual Lewis acid-Lewis base activators to provide a varied repertoire of functionality-rich alpha,beta-unsaturated-gamma-amino-delta-silyloxy carbonyl structures, in useful yields and often with an exquisite level of diastereoselection.

引用

页码：5446 / 5451

页数：6

共 33 条

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