Computer software for performing likelihood tests of pedigree relationship using genetic markers

被引:414
作者
Goodnight, KF [1 ]
Queller, DC [1 ]
机构
[1] Rice Univ, Dept Ecol & Evolutionary Biol MS170, Houston, TX 77005 USA
关键词
kinship; likelihood; parentage; pedigree; relatedness; software;
D O I
10.1046/j.1365-294x.1999.00664.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular techniques are making ever more genetic markers available for use in parentage assignment and measures of relatedness. We present a program, Kinship, designed to use likelihood techniques to test for any non-inbred pedigree relationship between pairs of individuals, using single-locus codominant genetic markers. Kinship calculates the likelihood that each pair of individuals in a data set are related by a given pedigree hypothesis, and likelihood ratios for any pair of hypotheses. The program also uses a simulation routine to attach statistical significance to its results.
引用
收藏
页码:1231 / 1234
页数:4
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