Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal

被引：334

作者：

Krampera, Mauro ^{[1
]}

Galipeau, Jacques ^{[2
]}

Shi, Yufang ^{[3
,4
]}

Tarte, Karin ^{[5
,6
]}

Sensebe, Luc ^{[5
,7
]}

机构：

[1] Univ Verona, Dept Med, Sect Hematol, Stem Cell Res Lab,Policlin GB Rossi, I-37134 Verona, Italy

[2] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[3] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China

[5] Etab Francais Sang, St Denis, France

[6] Univ Rennes 1, INSERM, U917, Rennes, France

[7] Fac Med Toulouse, INSERM, U1031, STROMALab CNRS EFS UPS UMR5273, F-31073 Toulouse, France

来源：

CYTOTHERAPY | 2013年 / 15卷 / 09期

关键词：

immune regulation; ISCT; mesenchymal stromal cells; MSC; regulatory properties; standardization; VERSUS-HOST-DISEASE; STEM-CELLS; BONE-MARROW; PERIVASCULAR CELLS; STEROID-RESISTANT; INTERFERON-GAMMA; ADIPOSE-TISSUE; INHIBIT; PROLIFERATION; MSC;

D O I：

10.1016/j.jcyt.2013.02.010

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Cultured mesenchymal stromal cells (MSCs) possess immune regulatory properties and are already used for clinical purposes, although preclinical data (both in vitro and in vivo in animal models) are not always homogeneous and unequivocal. However, the various MSC-based clinical approaches to treat immunological diseases would be significantly validated and strengthened by using standardized immune assays aimed at obtaining shared, reproducible and consistent data. Thus, the MSC Committee of the International Society for Cellular Therapy has decided to put forward for general discussion a working proposal for a standardized approach based on a critical view of literature data.

引用

页码：1054 / 1061

页数：8

共 65 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2]

Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth:: role of stromal cells in follicular lymphoma pathogenesis [J].

Ame-Thomas, Patricia ;

Maby-El Hajjami, Helene ;

Monvoisin, Celine ;

Jean, Rachel ;

Monnier, Delphine ;

Caulet-Maugendre, Sylvie ;

Guillaudeux, Thierry ;

Lamy, Thierry ;

Fest, Thierry ;

Tarte, Karin .

BLOOD, 2007, 109 (02) :693-702

[3]

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[4]

Comparison of stem-cell-mediated osteogenesis and dentinogenesis [J].

Batouli, S ;

Miura, M ;

Brahim, J ;

Tsutsui, TW ;

Fisher, LW ;

Gronthos, S ;

Robey, PG ;

Shi, S .

JOURNAL OF DENTAL RESEARCH, 2003, 82 (12) :976-981

[5]

Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages [J].

Brachvogel, B ;

Moch, H ;

Pausch, F ;

Schlötzer-Schrehardt, U ;

Hofmann, C ;

Hallmann, R ;

von der Mark, K ;

Winkler, T ;

Pöschl, E .

DEVELOPMENT, 2005, 132 (11) :2657-2668

[6]

Toll-Like Receptor-3-Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils [J].

Cassatella, Marco A. ;

Mosna, Federico ;

Micheletti, Alessandra ;

Lisi, Veronica ;

Tamassia, Nicola ;

Cont, Caterina ;

Calzetti, Federica ;

Pelletier, Martin ;

Pizzolo, Giovanni ;

Krampera, Mauro .

STEM CELLS, 2011, 29 (06) :1001-1011

[7]

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ [J].

Chan, Jennifer L. ;

Tang, Katherine C. ;

Patel, Anoop P. ;

Bonilla, Larissa M. ;

Pierobon, Nicola ;

Ponzio, Nicholas M. ;

Rameshwar, Pranela .

BLOOD, 2006, 107 (12) :4817-4824

[8]

Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis [J].

Constantin, Gabriela ;

Marconi, Silvia ;

Rossi, Barbara ;

Angiari, Stefano ;

Calderan, Laura ;

Anghileri, Elena ;

Gini, Beatrice ;

Bach, Simone Dorothea ;

Martinello, Marianna ;

Bifari, Francesco ;

Galie, Mirco ;

Turano, Ermanna ;

Budui, Simona ;

Sbarbati, Andrea ;

Krampera, Mauro ;

Bonetti, Bruno .

STEM CELLS, 2009, 27 (10) :2624-2635

[9]

Human mesenchymal stem cells modulate B-cell functions [J].

Corcione, A ;

Benvenuto, F ;

Ferretti, E ;

Giunti, D ;

Cappiello, V ;

Cazzanti, F ;

Risso, M ;

Gualandi, F ;

Mancardi, GL ;

Pistoia, V ;

Uccelli, A .

BLOOD, 2006, 107 (01) :367-372

[10]

Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts [J].

Covas, Dimas T. ;

Panepucci, Rodrigo A. ;

Fontes, Aparecida M. ;

Silva, Wilson A., Jr. ;

Orellana, Maristela D. ;

Freitas, Marcela C. C. ;

Neder, Luciano ;

Santos, Anemari R. D. ;

Peres, Luiz C. ;

Jamur, Maria C. ;

Zago, Marco A. .

EXPERIMENTAL HEMATOLOGY, 2008, 36 (05) :642-654

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