Immunity to Onchocerca spp. in animal hosts

被引：27

作者：

Abraham, D

Lucius, R

Trees, AJ

机构：

[1] Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA

[2] Humboldt Univ, Inst Biol, Lehrstuhl Mol Parasitol, D-10115 Berlin, Germany

[3] Univ Liverpool, Liverpool Sch Trop Med, Dept Vet Parasitol, Liverpool L3 5QA, Merseyside, England

[4] Univ Liverpool, Fac Vet Sci, Liverpool L3 5QA, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2002年 / 18卷 / 04期

关键词：

D O I：

10.1016/S1471-4922(02)02245-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca, volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.

引用

页码：164 / 171

页数：8

共 68 条

[1] IDENTIFICATION OF SURROGATE RODENT HOSTS FOR LARVAL ONCHOCERCA-LIENALIS AND INDUCTION OF PROTECTIVE IMMUNITY IN A MODEL SYSTEM [J].