Divergent effect of acute and chronic alcohol on arterial stiffness

被引：70

作者：

Mahmud, A

Feely, J ^{[1
]}

机构：

[1] St James Hosp, Trinity Ctr Hlth Sci, Dept Pharmacol & Therapeut, Hypertens Cli, Dublin 8, Ireland

[2] Trinity Coll Dublin, Dept Pharmacol & Therapeut, Dublin, Ireland

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2002年 / 15卷 / 03期

关键词：

alcohol; blood pressure; arterial stiffness;

D O I：

10.1016/S0895-7061(01)02315-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To study the effects of alcohol on large artery function we measured arterial wave reflection in the aorta as augmentation index (AI%) by applanation tonometry in 324 subjects (18 to 86 years, 223 male). In eight subjects, when ingested acutely, red wine containing alcohol (0.8 g/kg), but not dealcoholized wine, reduced (P < .01) blood pressure (BP), pulse wave velocity, and AI%. Men with an excessive alcohol consumption (>21 units/week) had a higher AI% (12 +/- 2 v 5 +/- 2, P < .05) and BP, particularly aortic systolic, than did those with a lesser intake. This study suggests that alcohol when ingested acutely may reduce arterial stiffness, although alcohol when ingested chronically, in excess, increases it. Am J Hypertens 2002:15:240-243 (C) 2002 American Journal of Hypertension, Ltd.

引用

页码：240 / 243

页数：4

共 15 条

[1] Beneficial vs. detrimental actions of ethanol on heart and coronary vascular muscle: Roles of Mg2+ and Ca2+ [J].