In rats, odor-induced Fos in the olfactory pathways depends on the phase of the circadian clock

被引:38
作者
Amir, S [1 ]
Cain, S [1 ]
Sullivan, J [1 ]
Robinson, B [1 ]
Stewart, J [1 ]
机构
[1] Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada
基金
英国医学研究理事会; 加拿大自然科学与工程研究理事会;
关键词
olfactory system; olfactory stimulation; Fos; immunocytochemistry; circadian rhythm; rat;
D O I
10.1016/S0304-3940(99)00609-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We used immunostaining for Fos to study the effect of circadian clock phase on odor-induced neuronal activation in the olfactory system in rats. Brief presentation of cedar odor to rats housed in constant darkness stimulated Fos expression in the main olfactory bulb, anterior olfactory nucleus, piriform cortex, and several other odor-responsive structures, both in the subjective day and subjective night phases of the cycle. Fos expression in response to odor, but not basal expression, was greatly enhanced in the subjective night in ail structures examined. These findings are consistent with the idea that odor-induced neuronal activation in the olfactory pathways is modulated by the phase of the circadian clock. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:175 / 178
页数:4
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