Actin nucleation: Nucleation-promoting factors are not all equal

被引：11

作者：

Higgs, HN ^{[1
]}

机构：

[1] Dartmouth Coll Sch Med, Dept Biochem, Hanover, NH 03755 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 24期

关键词：

D O I：

10.1016/S0960-9822(01)00612-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arp2/3 complex plays a key role in regulated actin polymerization. A recent study has revealed marked differences in the ability of two nucleation-promoting factors - N-WASP and Scar/WAVE1 - to activate the Arp2/3 complex. Further insights have come from determination of the Arp2/3 crystal structure.

引用

页码：R1009 / R1012

页数：4

共 20 条

[1] Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation [J].

Bailly, M ;

Macaluso, F ;

Cammer, M ;

Chan, A ;

Segall, JE ;

Condeelis, JS .

JOURNAL OF CELL BIOLOGY, 1999, 145 (02) :331-345

[2] Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks [J].

Blanchoin, L ;

Pollard, TD ;

Mullins, RD .

CURRENT BIOLOGY, 2000, 10 (20) :1273-1282

[3] Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins [J].

Blanchoin, L ;

Amann, KJ ;

Higgs, HN ;

Marchand, JB ;

Kaiser, DA ;

Pollard, TD .

NATURE, 2000, 404 (6781) :1007-1011

[4] Dendritic organization of actin comet tails [J].

Cameron, LA ;

Svitkina, TM ;

Vignjevic, D ;

Theriot, JA ;

Borisy, GG .

CURRENT BIOLOGY, 2001, 11 (02) :130-135

[5] Activation of the Arp2/3 complex by the actin filament binding protein Abp1p [J].

Goode, BL ;

Rodal, AA ;

Barnes, G ;

Drubin, DG .

JOURNAL OF CELL BIOLOGY, 2001, 153 (03) :627-634

[6] Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins [J].

Higgs, HN ;

Pollard, TD .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :649-676

[7] SEQUENCES, STRUCTURAL MODELS, AND CELLULAR-LOCALIZATION OF THE ACTIN-RELATED PROTEINS ARP2 AND ARP3 FROM ACANTHAMOEBA [J].

KELLEHER, JF ;

ATKINSON, SJ ;

POLLARD, TD .

JOURNAL OF CELL BIOLOGY, 1995, 131 (02) :385-397

[8] Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex [J].

Machesky, LM ;

Insall, RH .

CURRENT BIOLOGY, 1998, 8 (25) :1347-1356

[9] Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex [J].

Marchand, JB ;

Kaiser, DA ;

Pollard, TD ;

Higgs, HN .

NATURE CELL BIOLOGY, 2001, 3 (01) :76-82

[10] The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments [J].

Mullins, RD ;

Heuser, JA ;

Pollard, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6181-6186

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