Aryllithium compounds bearing alkoxycarbonyl groups: Generation and reactions using a microflow system

被引：136

作者：

Nagaki, Aiichiro ^{[1
]}

Kim, Heejin ^{[1
]}

Yoshida, Jun-ichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Synthet & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 41期

基金：

日本学术振兴会;

关键词：

arenes; electrophilic substitution; lithiation; microreactors; reactive intermediates;

D O I：

10.1002/anie.200803205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Go with the flow: An effective method for the generation and reaction of aryllithium compounds bearing an alkoxycarbonyl group is developed using microflow systems with very short residence times together with fast mixing and efficient temperature control. A wide range of alkoxycarbonyl groups including ethoxycarbonyl and methoxycarbonyl groups are tolerant of the microflow conditions. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7833 / 7836

页数：4

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