Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

被引：1639

作者：

Fraser, Abigail ^{[1
,2
]}

Macdonald-Wallis, Corrie ^{[1
,2
]}

Tilling, Kate ^{[2
]}

Boyd, Andy ^{[2
]}

Golding, Jean ^{[2
]}

Smith, George Davey ^{[1
,2
]}

Henderson, John ^{[2
]}

Macleod, John ^{[2
]}

Molloy, Lynn ^{[2
]}

Ness, Andy ^{[3
]}

Ring, Susan ^{[2
]}

Nelson, Scott M. ^{[4
]}

Lawlor, Debbie A. ^{[1
,2
]}

机构：

[1] Univ Bristol, Ctr Causal Anal Translat Epidemiol, MRC, Bristol BS8 2BN, Avon, England

[2] Univ Bristol, Sch Social & Community Med, Bristol BS8 2BN, Avon, England

[3] Univ Bristol, Sch Oral & Dent Sci, Bristol BS8 2BN, Avon, England

[4] Univ Glasgow, Sch Med, Glasgow G12 8QQ, Lanark, Scotland

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2013年 / 42卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

BODY-MASS INDEX; MATERNAL ANTENATAL ANXIETY; BLOOD-PRESSURE CHANGE; BEHAVIOURAL/EMOTIONAL PROBLEMS; MENDELIAN RANDOMIZATION; HYPERTENSIVE DISORDERS; PREGNANCY FINDINGS; RISK-FACTORS; WEIGHT-GAIN; ALCOHOL-USE;

D O I：

10.1093/ije/dys066

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19-22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17-18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on > 10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.

引用

页码：97 / 110

页数：14

共 69 条

[1] Intrauterine Exposure to Alcohol and Tobacco Use and Childhood IQ: Findings from a Parental-Offspring Comparison within the Avon Longitudinal Study of Parents and Children [J].