Expression of NF- κ B and osteopontin of synovial fluid of patients with knee osteoarthritis

被引：32

作者：

Qin, Li-Feng ^{[1
]}

Wang, Wan-Chun ^{[1
]}

Fang, Han ^{[2
]}

Mao, Xin-Zhan ^{[1
]}

Huang, Guo-Liang ^{[1
]}

Chen, You ^{[1
]}

Zhou, Hou-De ^{[3
]}

Shen, Yi ^{[1
]}

Qin, Li-Hua ^{[4
]}

Peng, Dan ^{[1
]}

机构：

[1] Cent S Univ, Xiang Ya Hosp 2, Dept Orthoped, Changsha 410010, Hunan, Peoples R China

[2] Cent S Univ, Xiang Ya Hosp 2, Dept Cardiovasc Dis, Changsha 410008, Hunan, Peoples R China

[3] Cent S Univ, Xiang Ya Hosp 2, Dept Endocrinol, Changsha 410010, Hunan, Peoples R China

[4] Hunan Univ Chinese Med, Sch Nursing, Dept Gynecol, Changsha 410208, Hunan, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2013年 / 6卷 / 05期

关键词：

Osteoarthritis; Osteopontin; Synovial fluid;

D O I：

10.1016/S1995-7645(13)60042-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

OBJECTIVE: To explore the significance of osteopontin and nuclear factor kappa B (NF- kappa B) expression in patients with knee osteoarthritis. METHODS: RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF- kappa B concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them. RESULTS: OPN and NF- kappa B expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF- kappa B expression levels (P<0.05). CONCLUSIONS: The high expression of OPN and NF- kappa B are closely related to occurrence and development of knee osteoarthritis.

引用

页码：379 / 382

页数：4

共 13 条

[1]

[Anonymous], 2013, INT J CLIN PHARM THE, DOI DOI 10.5414/CPP51035

[2]

Inhibition of transcription factor NF-κB reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells [J].

Bond, M ;

Chase, AJ ;

Baker, AH ;

Newby, AC .

CARDIOVASCULAR RESEARCH, 2001, 50 (03) :556-565

[3]

Ceng QY, 1998, CHIN J PRACT INTERN, V18, P108

[4]

[高曙光 Gao Shuguang], 2010, [中华骨科杂志, Chinese Journal of Orthopedics], V30, P672

[5]

Guo Jin-hai, 2012, Beijing Da Xue Xue Bao Yi Xue Ban, V44, P954

[6]

Jacson RW, 1992, OSTEOARTHRITIS DIAGN, P527

[7]

Osteopontin as a target for cancer therapy [J].

Johnston, Nicholas I. F. ;

Gunasekharan, Vignesh Kumar ;

Ravindranath, Amod ;

O'Connell, Ciara ;

Johnston, Patrick G. ;

El-Tanani, Mohamed K. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :4361-4372

[8]

Kaithwas Gaurav, 2012, Asian Pacific Journal of Tropical Biomedicine, V2, P185, DOI 10.1016/S2221-1691(12)60039-2

[9]

Role of Anterior Cruciate Ligament Reconstruction in Preventing Osteoarthritis [J].

Karahan, Mustafa .

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2012, 28 (12) :1750-1750

[10]

Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee FINNISH REGISTRY-BASED STUDY OF 3195 KNEES [J].

Niinimaki, T. T. ;

Eskelinen, A. ;

Mann, B. S. ;

Junnila, M. ;

Ohtonen, P. ;

Leppilahti, J. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2012, 94B (11) :1517-1521

← 1 2 →