The efficacy and safety of KL(4)-surfactant in infants with respiratory distress syndrome

被引:116
作者
Cochrane, CG
Revak, SD
Merritt, A
Heldt, GP
Hallman, M
Cunningham, MD
Easa, D
Pramanik, A
Edwards, DK
Alberts, MS
机构
[1] UNIV CALIF DAVIS, DEPT PEDIAT, SAN DIEGO, CA USA
[2] UNIV CALIF SAN DIEGO, DEPT PEDIAT, SAN DIEGO, CA 92103 USA
[3] UNIV CALIF IRVINE, DEPT PEDIAT, IRVINE, CA 92717 USA
[4] SADDLEBACK MEM MED CTR, LAGUNA HILLS, CA USA
[5] UNIV CALIF SAN DIEGO, DEPT RADIOL, SAN DIEGO, CA 92103 USA
[6] KAPIOLANI MED CTR WOMEN & CHILDREN, HONOLULU, HI USA
[7] LOUISIANA STATE UNIV, MED CTR, DEPT PEDIAT, SHREVEPORT, LA USA
关键词
D O I
10.1164/ajrccm.153.1.8542150
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL(4)), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS). The KL(4) peptide was synthesized to resemble the amino acid pattern of surfactant protein B (SP-B). Forty-seven infants with RDS were treated within 4 h of birth with the KL(4)-peptide/phospholipid mixture, called KL(4)-Surfactant. The average arterial-to-alveolar oxygen tension ratios (a/A O-2) of 39 patients included in efficacy analyses rose from pretreatment values of 0.14 +/- 0.02 (mean +/- SEM) to 0.40 +/- 0.04 (normal value greater than or equal to 0.40) by 12 h of age. Mean airway pressures and oxygenation index values fell concomitantly, and expansion of the lungs was observed on radiographs. The median duration of mechanical ventilation was 5.0 d. Of the 39 included infants, 29 required only a single dose. Radiographic data indicate that those patients requiring a second instillation of KL(4)-Surfactant but not showing a sustained rise in a/A O-2 ratios did, in fact, exhibit expansion of alveoli in the lung. There were no RDS-related deaths; the incidence of complications was no higher than found in other comparable published studies. The data demonstrate that the synthetic peptide, KL(4), which mimics the hydrophobic and hydrophilic pattern of SP-B, when formulated in an aqueous dispersion with the phospholipids DPPC and POPG, creates a strong and durable surfactant activity as judged by expansion of pulmonary alveoli and improvement of gas exchange in infants with RDS.
引用
收藏
页码:404 / 410
页数:7
相关论文
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