Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors

被引：48

作者：

Gilmore, JL

Hays, SJ

Caprathe, BW

Lee, C

Emmerling, MR

Michael, W

Jaen, JC

机构：

[1] Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00094-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-aryl-4H-3,1-benzoxazin-4-ones have been synthesized and tested for inhibitory activity against Clr serine protease. Compounds were found that were equipotent and more selective than the reference compound FUT-175.

引用

页码：679 / 682

页数：4

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