Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

被引：28

作者：

Ou, LS ^{[1
]}

See, LC ^{[1
]}

Wu, CJ ^{[1
]}

Kao, CC ^{[1
]}

Lin, YL ^{[1
]}

Huang, JL ^{[1
]}

机构：

[1] Chang Gung Childrens Hosp, Dept Pediat, Div Allergy Asthma & Rheumatol, Tao Yuan, Taiwan

来源：

CLINICAL RHEUMATOLOGY | 2002年 / 21卷 / 01期

关键词：

cytokine; IL-1; IL-6; juvenile idiopathic arthritis; juvenile rheumatoid arthritis; osteocalcin; TNF-alpha;

D O I：

10.1007/s100670200012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1beta was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were Significantly lower. Osteocalcin levels were decreased and TNF-alpha increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.

引用

页码：52 / 56

页数：5

共 44 条

[1] ALARCONRIQUELME ME, 1988, J RHEUMATOL, V15, P1547
[2] Brewer E J Jr, 1977, Arthritis Rheum, V20, P195
[3] DAVID J, 1990, ARTHRITIS RHEUM, V33, P118
[4] CACHECTIN TUMOR NECROSIS FACTOR STIMULATES COLLAGENASE AND PROSTAGLANDIN-E2 PRODUCTION BY HUMAN SYNOVIAL-CELLS AND DERMAL FIBROBLASTS
DAYER, JM
BEUTLER, B
CERAMI, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (06) : 2163 - 2168
[5] De Benedetti F, 1998, J RHEUMATOL, V25, P203
[6] De Benedetti Fabrizio, 1997, Current Opinion in Rheumatology, V9, P428, DOI 10.1097/00002281-199709000-00009
[7] DEBenedetti F, 1995, CLIN EXP RHEUMATOL, V13, P779
[8] DEBENEDETTI F, 1992, CLIN EXP RHEUMATOL, V10, P493
[9] CORRELATION OF SERUM INTERLEUKIN-6 LEVELS WITH JOINT INVOLVEMENT AND THROMBOCYTOSIS IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS
DEBENEDETTI, F
MASSA, M
ROBBIONI, P
RAVELLI, A
BURGIO, GR
MARTINI, A
[J]. ARTHRITIS AND RHEUMATISM, 1991, 34 (09): : 1158 - 1163
[10] DIGIOVINE FS, 1988, IMMUNOPATHOGENIC MEC, P101

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