The 3′-5′ exonucleases

被引：229

作者：

Shevelev, IV

Hübscher, U

机构：

[1] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

[2] Petersburg Nucl Phys Inst, Dept Mol & Radiat Biophys, Gatchina 188300, Leningrad Distr, Russia

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrm804

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Over the past few years, several new 3'-5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3'-5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3'-5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.

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页码：364 / 375

页数：12

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