A cut above the rest? - MMP-8 and liver fibrosis gene therapy

被引：10

作者：

Iredale, JP ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

来源：

GASTROENTEROLOGY | 2004年 / 126卷 / 04期

关键词：

D O I：

10.1053/j.gastro.2004.01.060

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：1199 / 1201

页数：3

共 19 条

[1] MATRIX METALLOPROTEINASE-2 IS AN INTERSTITIAL COLLAGENASE - INHIBITOR-FREE ENZYME CATALYZES THE CLEAVAGE OF COLLAGEN FIBRILS AND SOLUBLE NATIVE TYPE-I COLLAGEN GENERATING THE SPECIFIC 3/4-LENGTH AND 1/4-LENGTH FRAGMENTS [J].

AIMES, RT ;

QUIGLEY, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) :5872-5876

[2] Hepatic stellate cells as a target for the treatment of liver fibrosis [J].

Bataller, R ;

Brenner, DA .

SEMINARS IN LIVER DISEASE, 2001, 21 (03) :437-451

[3] Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver [J].

Benyon, RC ;

Iredale, JP ;

Goddard, S ;

Winwood, PJ ;

Arthur, MJP .

GASTROENTEROLOGY, 1996, 110 (03) :821-831

[4] Extracellular matrix degradation and the role of hepatic stellate cells [J].

Benyon, RC ;

Arthur, MJP .

SEMINARS IN LIVER DISEASE, 2001, 21 (03) :373-384

[5]

Dudás J, 2001, AM J CLIN PATHOL, V115, P725

[6] Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury [J].

Friedman, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) :2247-2250

[7] History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells [J].

Geerts, A .

SEMINARS IN LIVER DISEASE, 2001, 21 (03) :311-335

[8] MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover [J].

Holmbeck, K ;

Bianco, P ;

Caterina, J ;

Yamada, S ;

Kromer, M ;

Kuznetsov, SA ;

Mankani, M ;

Robey, PG ;

Poole, AR ;

Pidoux, I ;

Ward, JM ;

Birkedal-Hansen, H .

CELL, 1999, 99 (01) :81-92

[9] Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat [J].

Iimuro, Y ;

Nishio, T ;

Morimoto, T ;

Nitta, T ;

Stefanovic, B ;

Choi, SK ;

Brenner, DA ;

Yamaoka, Y .

GASTROENTEROLOGY, 2003, 124 (02) :445-458

[10] Mechanisms of spontaneous resolution of rat liver fibrosis - Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors [J].

Iredale, JP ;

Benyon, RC ;

Pickering, J ;

McCullen, M ;

Northrop, M ;

Pawley, S ;

Hovell, C ;

Arthur, MJP .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (03) :538-549

← 1 2 →