METHODS TO MONITOR AUTOPHAGY OF SALMONELLA ENTERICA SEROVAR TYPHIMURIUM

被引：7

作者：

Birmingham, Cheryl L. ^{[1
,2
]}

Brumell, John H. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] Hosp Sick Children, Cell Biol Program, Toronto, ON M5G 1X8, Canada

来源：

METHODS IN ENZYMOLOGY: AUTOPHAGY IN MAMMALIAN SYSTEMS, VOL 452, PT B | 2009年 / 452卷

关键词：

GENOME-WIDE ASSOCIATION; LYSOSOMAL MEMBRANE-GLYCOPROTEINS; III SECRETION SYSTEM; CONTAINING VACUOLES; YERSINIA-PSEUDOTUBERCULOSIS; EPITHELIAL-CELLS; VIRULENCE GENES; CROHN-DISEASE; INVASION; SUSCEPTIBILITY;

D O I：

10.1016/S0076-6879(08)03620-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is an important component of the mammalian innate immune system and is able to specifically target intracellular bacterial pathogens. Salmonella enterica serovar Typhimurium is an intracellular pathogen that causes gastroenteritis in humans. Autophagy has been shown to target S. Typhimurium during in vitro infection of mammalian cultured cells and protects the cytosol of these cells from bacterial colonization. Here we discuss autophagic sequestration of S. Typhimurium and how it can be used as a model system to study the mechanisms of autophagy.

引用

页码：325 / 343

页数：19

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