共 209 条
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
被引:655
作者:

Schickel, R.
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机构:
Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

Boyerinas, B.
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Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

Park, S-M
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Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

Peter, M. E.
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机构:
Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
机构:
[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
来源:
关键词:
apoptosis;
miRNA;
oncomiRs;
tumor progression;
D O I:
10.1038/onc.2008.274
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Micro (mi)RNAs are small, highly conserved noncoding RNAs that control gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Each miRNA is believed to regulate the expression of multiple mRNA targets, and many miRNAs have been linked to the initiation and progression of human cancer. miRNAs control various activities of the immune system and different stages of hematopoietic development, and their misexpression is the cause of various blood malignancies. Certain miRNAs have oncogenic activities, whereas others have the potential to act as tumor suppressors. Because they control fundamental processes such as differentiation, cell growth and cell death, the study of the role of miRNAs in human neoplasms holds great promise for novel forms of therapy. Here, we summarize the role of miRNAs and their targets in contributing to human cancers and their function as regulators of apoptotic pathways and the immune system.
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收藏
页码:5959 / 5974
页数:16
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