MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

被引:655
作者
Schickel, R. [1 ]
Boyerinas, B. [1 ]
Park, S-M [1 ]
Peter, M. E. [1 ]
机构
[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA
关键词
apoptosis; miRNA; oncomiRs; tumor progression;
D O I
10.1038/onc.2008.274
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Micro (mi)RNAs are small, highly conserved noncoding RNAs that control gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Each miRNA is believed to regulate the expression of multiple mRNA targets, and many miRNAs have been linked to the initiation and progression of human cancer. miRNAs control various activities of the immune system and different stages of hematopoietic development, and their misexpression is the cause of various blood malignancies. Certain miRNAs have oncogenic activities, whereas others have the potential to act as tumor suppressors. Because they control fundamental processes such as differentiation, cell growth and cell death, the study of the role of miRNAs in human neoplasms holds great promise for novel forms of therapy. Here, we summarize the role of miRNAs and their targets in contributing to human cancers and their function as regulators of apoptotic pathways and the immune system.
引用
收藏
页码:5959 / 5974
页数:16
相关论文
共 209 条
[1]   The let-7 microRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans [J].
Abbott, AL ;
Alvarez-Saavedra, E ;
Miska, EA ;
Lau, NC ;
Bartel, DP ;
Horvitz, HR ;
Ambros, V .
DEVELOPMENTAL CELL, 2005, 9 (03) :403-414
[2]   An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue [J].
Abe, N ;
Watanabe, T ;
Suzuki, Y ;
Matsumoto, N ;
Masaki, T ;
Mori, T ;
Sugiyama, M ;
Chiappetta, G ;
Fusco, A ;
Atomi, Y .
BRITISH JOURNAL OF CANCER, 2003, 89 (11) :2104-2109
[3]   Enhanced and accelerated lymphoproliferation in Fas-null mice [J].
Adachi, M ;
Suematsu, S ;
Suda, T ;
Watanabe, D ;
Fukuyama, H ;
Ogasawara, J ;
Tanaka, T ;
Yoshida, N ;
Nagata, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :2131-2136
[4]   Downregulation of microRNAs-143 and-145 in B-cell malignancies [J].
Akao, Yukihiro ;
Nakagawa, Yoshihito ;
Kitade, Yukio ;
Kinoshita, Tomohiro ;
Naoe, Tomoki .
CANCER SCIENCE, 2007, 98 (12) :1914-1920
[5]   let-7 microRNA functions as a potential growth suppressor in human colon cancer cells [J].
Akao, Yukihiro ;
Nakagawa, Yoshihito ;
Naoe, Tomoki .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (05) :903-906
[6]   Two CD95 tumor classes with different sensitivities to antitumor drugs [J].
Algeciras-Schimnich, A ;
Pietras, EM ;
Barnhart, BC ;
Legembre, P ;
Vijayan, S ;
Holbeck, SL ;
Peter, ME .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11445-11450
[7]   Apoptosis-independent functions of killer caspases [J].
Algeciras-Schimnich, A ;
Barnhart, BC ;
Peter, ME .
CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (06) :721-726
[8]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[9]   miRNAs: Micro managers of programmed cell death [J].
Baehrecke, EH .
CURRENT BIOLOGY, 2003, 13 (12) :R473-R475
[10]   The CD95 type I/type II model [J].
Barnhart, BC ;
Alappat, EC ;
Peter, ME .
SEMINARS IN IMMUNOLOGY, 2003, 15 (03) :185-193