Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

被引:315
作者
Figee, Martijn [1 ,2 ]
Luigjes, Judy [1 ,2 ]
Smolders, Ruud [1 ,2 ]
Valencia-Alfonso, Carlos-Eduardo [1 ,3 ]
van Wingen, Guido [1 ,2 ]
de Kwaasteniet, Bart [1 ,2 ]
Mantione, Mariska [1 ]
Ooms, Pieter [1 ]
de Koning, Pelle [1 ]
Vulink, Nienke [1 ]
Levar, Nina [1 ,2 ]
Droge, Lukas [1 ]
van den Munckhof, Pepijn [4 ]
Schuurman, P. Richard [4 ]
Nederveen, Aart [2 ,5 ]
van den Brink, Wim [1 ]
Mazaheri, Ali [1 ]
Vink, Matthijs [6 ]
Denys, Damiaan [1 ,3 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Brain Imaging Ctr, NL-1105 AZ Amsterdam, Netherlands
[3] Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Neurosurg, NL-1105 AZ Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands
[6] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands
关键词
FUNCTIONAL CONNECTIVITY;
D O I
10.1038/nn.3344
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.
引用
收藏
页码:386 / U195
页数:4
相关论文
共 20 条
[1]  
[Anonymous], 2005, Technical Report A-6
[2]   Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression [J].
Bewernick, Bettina H. ;
Hurlemann, Rene ;
Matusch, Andreas ;
Kayser, Sarah ;
Grubert, Christiane ;
Hadrysiewicz, Barbara ;
Axmacher, Nikolai ;
Lemke, Matthias ;
Cooper-Mahkorn, Deirdre ;
Cohen, Michael X. ;
Brockmann, Holger ;
Lenartz, Doris ;
Sturm, Volker ;
Schlaepfer, Thomas E. .
BIOLOGICAL PSYCHIATRY, 2010, 67 (02) :110-116
[3]   EEGLAB, SIFT, NFT, BCILAB, and ERICA: New Tools for Advanced EEG Processing [J].
Delorme, Arnaud ;
Mullen, Tim ;
Kothe, Christian ;
Acar, Zeynep Akalin ;
Bigdely-Shamlo, Nima ;
Vankov, Andrey ;
Makeig, Scott .
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE, 2011, 2011
[4]   Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder [J].
Denys, Damiaan ;
Mantione, Mariska ;
Figee, Martijn ;
van den Munckhof, Pepijn ;
Koerselman, Frank ;
Westenberg, Herman ;
Bosch, Andries ;
Schuurman, Rick .
ARCHIVES OF GENERAL PSYCHIATRY, 2010, 67 (10) :1061-1068
[5]   Functional Connectivity of Human Striatum: A Resting State fMRI Study [J].
Di Martino, A. ;
Scheres, A. ;
Margulies, D. S. ;
Kelly, A. M. C. ;
Uddin, L. Q. ;
Shehzad, Z. ;
Biswal, B. ;
Walters, J. R. ;
Castellanos, F. X. ;
Milham, M. P. .
CEREBRAL CORTEX, 2008, 18 (12) :2735-2747
[6]   Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder [J].
Figee, Martijn ;
Vink, Matthijs ;
de Geus, Femke ;
Vulink, Nienke ;
Veltman, Dick J. ;
Westenberg, Herman ;
Denys, Damiaan .
BIOLOGICAL PSYCHIATRY, 2011, 69 (09) :867-874
[7]  
GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
[8]   Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning [J].
Haber, Suzanne N. ;
Kim, Ki-Sok ;
Mailly, Philippe ;
Calzavara, Roberta .
JOURNAL OF NEUROSCIENCE, 2006, 26 (32) :8368-8376
[9]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62
[10]   Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder [J].
Harrison, Ben J. ;
Soriano-Mas, Carles ;
Pujol, Jesus ;
Ortiz, Hector ;
Lopez-Sola, Marina ;
Hernandez-Ribas, Rosa ;
Deus, Joan ;
Alonso, Pino ;
Yuecel, Murat ;
Pantelis, Christos ;
Menchon, Jose M. ;
Cardoner, Narcis .
ARCHIVES OF GENERAL PSYCHIATRY, 2009, 66 (11) :1189-1200