Transient receptor potential vanilloid in blood pressure regulation

Purpose of review The involvement of neurohormonal factors in the pathogenesis of hypertension has been extensively studied. However, the mechanisms underlying the role of the transient receptor potential vanilloid type 1 (TRPV1) channels in hypertension are still largely unknown. This review presents some of the most recent findings regarding the potential mechanisms of TRPV1 in mediating blood pressure, the pathophysiology of hypertension, and its related disorders. Recent findings TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators. TRPV1 also interacts with various physiological and pathophysiological systems involved in salt and water homeostasis and cardiovascular homeostasis. Impairment of TRPV1 signaling may contribute to the pathogenesis of diseases such as hypertension, heart failure, atherosclerosis, diabetes, obesity, myocardial ischemia, and stroke. Summary Accumulating evidence implicates TRPV1 as serving a key role in cardiovascular health by regulating cardiovascular function and protecting against cardiovascular injury. Given the large prevalence of hypertension and its related disorders, the possible involvement of TRPV1 makes it a potential target of therapy for cardiovascular disease. Future study of TRPV1 may enhance our understanding of several cardiovascular diseases and may unveil novel pharmacological strategies for treating hypertension.