Practical Imidazole-Based Phosphine Ligands for Selective Palladium-Catalyzed Hydroxylation of Aryl Halides

被引：220

作者：

Schulz, Thomas ^{[1
]}

Torborg, Christian ^{[1
]}

Schaeffner, Benjamin ^{[1
]}

Huang, Jun ^{[1
]}

Zapf, Alexander ^{[1
]}

Kadyrov, Renat ^{[2
]}

Boerner, Armin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

[2] Evonik Dugussa GmbH, Business Line Catalysis, D-63457 Hanau, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 05期

关键词：

chemoselectivity; homogeneous catalysis; hydroxylation; palladium; phosphines; N BOND FORMATION; ALPHA-ARYLATION; GENERAL-METHOD; C-N; COUPLING REACTIONS; CROSS-COUPLINGS; AMINATION; CHLORIDES; ESTERS; ETHERS;

D O I：

10.1002/anie.200804898

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The phenol countdown: Novel imidazole-based phosphine ligands are synthesized on scales up to 100 g by a convenient lithiation-phosphorylation method. The phosphines are stable towards air and moisture and are successfully applied as ligands in the palladium-catalyzed selective hydroxylation of aryl halides (see scheme, dba=dibenzylideneacetone). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：918 / 921

页数：4

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