Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry

被引：206

作者：

Miao, XS ^{[1
]}

Koenig, BG ^{[1
]}

Metcalfe, CD ^{[1
]}

机构：

[1] Trent Univ, Water Qual Ctr, Peterborough, ON K9J 7B8, Canada

来源：

JOURNAL OF CHROMATOGRAPHY A | 2002年 / 952卷 / 1-2期

关键词：

tandem mass spectrometry; electrospray ionization; acidic drugs;

D O I：

10.1016/S0021-9673(02)00088-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous analysis of nine acidic pharmaceutical drugs (bezafibrate. clofibric acid, diclofenac, fenoprofen, gemfibrozil, ibuprofen, indomethacin, ketoprofen and naproxen) in sewage treatment plant (STP) effluents. The mean recoveries of the pharmaceuticals ranged front 58.9 to 91.5% in STP effluent. and the limits of detection of the analytes were 5-20 ng/ml. The method was applied to the quantitative analysis of acidic drugs in the effluents from three Canadian STPs, in which bezafibrate, diclofenac. fenoprofen, gemfibrozil, ibuprofen. indomethacin and naproxen were detected. (C) 2002 Published by Elsevier Science B.V.

引用

页码：139 / 147

页数：9

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