The power of evolution: accessing the synthetic potential of P450s

被引：12

作者：

Roberts, GCK ^{[1
]}

机构：

[1] Univ Leicester, Ctr Mechanisms Human Toxic, Leicester LE1 9HN, Leics, England

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 10期

关键词：

D O I：

10.1016/S1074-5521(00)80013-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochromes P450 can catalyse hydroxylation reactions that are of considerable potential synthetic value, but a number of practical difficulties have hitherto prevented their use for this purpose. Recent advances, including intelligently designed laboratory evolution experiments, promise to overcome these obstacles, and to add P450s to the enzymatic armoury of the chemist.

引用

页码：R269 / R272

页数：4

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