Circulating blood markers and functional impairment in peripheral arterial disease

被引：53

作者：

McDermott, Mary M. ^{[1
,2
]}

Liu, Kiang ^{[2
]}

Ferrucci, Luigi ^{[4
]}

Tian, Lu ^{[2
]}

Guralnik, Jack M. ^{[5
]}

Green, David ^{[1
]}

Tan, Jin ^{[2
]}

Liao, Yihua ^{[2
]}

Pearce, William H. ^{[3
]}

Schneider, Joseph R. ^{[3
,6
]}

McCue, Kimberly ^{[1
]}

Ridker, Paul ^{[7
]}

Rifai, Nader ^{[8
]}

Criqui, Michael H. ^{[9
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL 60611 USA

[4] NIA, Lab Clin Epidemiol, Baltimore, MD 21224 USA

[5] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[6] Northwestern Hosp, Dept Surg, Div Vasc Surg, Evanston, IL USA

[7] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[8] Harvard Univ, Childrens Hosp, Sch Med, Boston, MA 02115 USA

[9] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2008年 / 56卷 / 08期

基金：

美国国家卫生研究院;

关键词：

intermittent claudication; peripheral vascular disease; physical functioning; inflammation;

D O I：

10.1111/j.1532-5415.2008.01797.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

OBJECTIVES: To determine whether higher levels of inflammatory blood markers, D-dimer, and homocysteine were associated with greater impairment in lower extremity functioning in persons with peripheral arterial disease (PAD). DESIGN: Cross-sectional. SETTING: Three Chicago-area medical centers. PARTICIPANTS: Four hundred twenty-three persons with PAD (ankle-brachial index (ABI) < 0.90). MEASUREMENTS: Lower extremity performance was assessed using the 6-minute walk and with usual- and fast-paced 4-m walking speed. Blood markers were D-dimer, C-reactive protein (CRP), interleukin-6 (IL-6), Soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intracellular adhesion molecule-1 (sICAM-1), and homocysteine. Calf muscle area was measured using computed tomography. RESULTS: Adjusting for confounders, higher levels of D-dimer (P < .001), IL-6 (P < .001), sVCAM-1. (P = .006), CRP (P = .01), homocysteine (P = .004), and sICAM-1 (P = .046) were associated with poorer 6-minute walk performance. Higher levels of D-dimer (P < .001), IL-6 (P = .003), sVCAM-1 (P = .001), and homocysteine (P = .005) were associated with slower usual-paced 4-m walking speed. Higher levels of D-dimer, sVCAM-1, sICAM-1, IL-6, and homocysteine were associated with slower fast-paced walking speed. Results were attenuated after additional adjustment for calf muscle area. CONCLUSION: Higher levels of inflammation and D-dimer were associated with poorer lower extremity performance in participants with PAD, independent of confounders including ABI.

引用

页码：1504 / 1510

页数：7

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