Two-timing zinc finger transcription factors liaising with RNA

被引：33

作者：

Burdach, Jon ^{[1
,2
]}

O'Connell, Mitchell R. ^{[2
]}

Mackay, Joel P. ^{[2
]}

Crossley, Merlin ^{[1
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ Sydney, Sch Mol Biosci, Sydney, NSW 2006, Australia

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2012年 / 37卷 / 05期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

TUMOR SUPPRESSOR PROTEIN; INTERNAL CONTROL REGION; 5S RIBOSOMAL-RNA; WILMS-TUMOR; FACTOR-IIIA; XENOPUS OOCYTES; MESSENGER-RNA; BINDING-ACTIVITY; DNA RECOGNITION; FUNCTIONAL INTERACTIONS;

D O I：

10.1016/j.tibs.2012.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Classical zinc fingers (ZFs) are one of the most common protein domains in higher eukaryotes and have been known for almost 30 years to act as sequence-specific DNA-binding domains. This knowledge has come, however, from the study of a small number of archetypal proteins, and a larger picture is beginning to emerge that ZF functions are far more diverse than originally suspected. Here, we review the evidence that a subset of ZF proteins live double lives, binding to both DNA and RNA targets and frequenting both the cytoplasm and the nucleus. This duality can create an important additional level of gene regulation that serves to connect transcriptional and post-transcriptional control.

引用

页码：199 / 205

页数：7

共 73 条

[1] Genomic Analyses of Musashi1 Downstream Targets Show a Strong Association with Cancer-related Processes [J].

Abreu, Raquel de Sousa ;

Sanchez-Diaz, Patricia C. ;

Vogel, Christine ;

Burns, Suzanne C. ;

Ko, Daijin ;

Burton, Tarea L. ;

Vo, Dat T. ;

Chennasamudaram, Soudhamini ;

Le, Shu-Yun ;

Shapiro, Bruce A. ;

Penalva, Luiz O. F. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (18) :12125-12135

[2] Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains [J].

Arranz, V ;

Harper, F ;

Florentin, Y ;

Puvion, E ;

Kress, M ;

ErnoultLange, M .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (04) :2116-2126

[3] In-vitro dual binding activity of a evolutionarily related subgroup of hnRNP proteins [J].

Bandiera, A ;

Medic, N ;

Akindahunsi, AA ;

Manzini, G .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 268 (1-2) :121-127

[4]

Belak ZR, 2008, BIOCHEM CELL BIOL, V86, P31, DOI [10.1139/O07-155, 10.1139/o07-155]

[5] Assembly of the Yin Yang 1 transcription factor into messenger ribonucleoprotein particles requires direct RNA binding activity [J].

Belak, Zachery R. ;

Ovsenek, Nick .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (52) :37913-37920

[6] The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron [J].

Bor, Yeou-cherng ;

Swartz, Jennifer ;

Morrison, Avril ;

Rekosh, David ;

Ladomery, Michael ;

Hammarskjold, Marie-Louise .

GENES & DEVELOPMENT, 2006, 20 (12) :1597-1608

[7] Keep your fingers off my DNA: Protein-protein interactions mediated by C2H2 zinc finger domains [J].

Brayer, Kathryn J. ;

Segal, David J. .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2008, 50 (03) :111-131

[8] Zinc finger proteins: Getting a grip on RNA [J].

Brown, RS .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2005, 15 (01) :94-98

[9] The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer [J].

Calaluce, Robert ;

Gubin, Matthew M. ;

Davis, J. Wade ;

Magee, Joseph D. ;

Chen, Jing ;

Kuwano, Yuki ;

Gorospe, Myriam ;

Atasoy, Ulus .

BMC CANCER, 2010, 10

[10] RNA binding by the Wilms tumor suppressor zinc finger proteins [J].

Caricasole, A ;

Duarte, A ;

Larsson, SH ;

Hastie, ND ;

Little, M ;

Holmes, G ;

Todorov, I ;

Ward, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7562-7566

← 1 2 3 4 5 6 7 8 →