Adenovirus-mediated gene therapy of liver diseases

被引：44

作者：

Ilan, Y

Saito, H

Thummala, NR

Chowdhury, NR

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA

[2] Hadassah Univ Hosp, Div Med, Liver Unit, Jerusalem, Israel

[3] Keio Univ, Sch Med, Dept Med, Tokyo, Japan

[4] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[5] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

来源：

SEMINARS IN LIVER DISEASE | 1999年 / 19卷 / 01期

关键词：

adenoviral vectors; gene therapy; hereditary diseases; infectious diseases; hepatic malignancies;

D O I：

10.1055/s-2007-1007097

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recombinant adenoviruses can infect nondividing cells with high efficiency and are rapidly concentrated in the liver after systemic administration, making them attractive for use in liver-directed gene therapy. How ever, there are two hurdles to clinical application of these vectors. First, adenoviruses are episomal and have limited life spans within the cell. Second host antiviral immune responses reduce the duration of vector persistence and preclude long-term transgene expression by repeated injection of the vector Several strategies have been designed for abrogation of the specific antiadenoviral immune responses by modification of the host immune system or alteration of the vector These strategies and the use of adenoviral vectors for the treatment of hereditary, infectious, and malignant diseases of the liver are discussed in this review.

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页码：49 / 59

页数：11

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