Structure and function of matrix metalloproteinases and TIMPs

被引：2567

作者：

Nagase, H

Visse, R

Murphy, G

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst, Div Rheumatol, Dept Matrix Biol, London W6 8LH, England

[2] Univ Cambridge, Dept Oncol, Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 69卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.cardiores.2005.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology. (c) 2005 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：562 / 573

页数：12

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