Host genetic influences on HIV-1 pathogenesis

被引：85

作者：

Michael, NL ^{[1
]}

机构：

[1] Walter Reed Army Inst Res, Dept Mol Diagnost & Pathogenesis, Div Retrovirol, Rockville, MD 20850 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(99)80078-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.

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页码：466 / 474

页数：9

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