Effect of Cu,Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae

被引：44

作者：

Barker, MG ^{[1
]}

Brimage, LJE ^{[1
]}

Smart, KA ^{[1
]}

机构：

[1] Oxford Brookes Univ, Sch Biol & Mol Sci, Oxford OX3 0BP, England

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 177卷 / 02期

基金：

英国惠康基金;

关键词：

Saccharomyces cerevisiae; ageing; replicative senescence; superoxide dismutase; carbon source;

D O I：

10.1111/j.1574-6968.1999.tb13732.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of oxidative damage in determining the replicative lifespan of Saccharomyces cerevisiae was investigated using a wild-type haploid laboratory yeast and a Cu,Zn superoxide dismutase (sod1) mutant derivative on glucose, ethanol, glycerol and galactose media. SOD1 expression was necessary to ensure longevity on all carbon sources tested. Whilst carbon source and SOD1 gene expression do influence yeast lifespan, the relationship between the two factors is complex. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：199 / 204

页数：6

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