Comedolytic effect of topical retinaldehyde in the rhino mouse model

被引:21
作者
Fort-Lacoste, L [1 ]
Verscheure, Y [1 ]
Tisne-Versailles, J [1 ]
Navarro, R [1 ]
机构
[1] Ctr Expt & Pharmacocinet Campans, F-81106 Castres, France
关键词
rhino mouse; retinaldehyde; topical preparation; acne;
D O I
10.1159/000051376
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Retinaldehyde is a key molecule in the metabolism of vitamin A by keratinocytes. In order to evaluate its range of topical activity in acne, its comedolytic effect was compared to that of retinoic acid in the same vehicle, in the rhino mouse model. Methods: The animals were treated on the back daily for 5 consecutive days per week for 3 weeks. At the end of this period, histological slides were analyzed in order to quantify the features of comedones and epidermal thickness. Results: Topical treatment with a retinaldehyde (0.05% w/w) and a retinoic acid formulation (0.025% w/w) induced comedolysis and increased the epidermal thickness with the same intensity. Conclusion: These data indicate that retinaldehyde exerts a significant comedolytic activity.
引用
收藏
页码:33 / 35
页数:3
相关论文
共 6 条
[1]   HISTOLOGIC-CHANGES IN THE SKIN OF THE RHINO MOUSE (HRRHHRRH) INDUCED BY RETINOIDS [J].
ASHTON, RE ;
CONNOR, MJ ;
LOWE, NJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1984, 82 (06) :632-635
[2]  
BOUCLIER M, 1991, SKIN PHARMACOL, V4, P65
[3]  
MEZICK JA, 1985, MODELS DERMATOLOGY, V2, P59
[4]  
Pechere Marc, 1996, Journal of Investigative Dermatology, V106, P912
[5]   TOPICAL RETINALDEHYDE ON HUMAN SKIN - BIOLOGIC EFFECTS AND TOLERANCE [J].
SAURAT, JH ;
DIDIERJEAN, L ;
MASGRAU, E ;
PILETTA, PA ;
JACONI, S ;
CHATELLARDGRUAZ, D ;
GUMOWSKI, D ;
MASOUYE, I ;
SALOMON, D ;
SIEGENTHALER, G .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 103 (06) :770-774
[6]   A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: A multicenter trial [J].
Shalita, A ;
Weiss, JS ;
Chalker, DK ;
Ellis, CN ;
Greenspan, A ;
Katz, HI ;
Kantor, I ;
Millikan, LE ;
Swinehart, T ;
Swinyer, L ;
Whitmore, C ;
Baker, M ;
Czemielewski, J .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1996, 34 (03) :482-485