Catalytic Asymmetric Cross-Couplings of Racemic α-Bromoketones with Arylzinc Reagents

被引：124

作者：

Lundin, Pamela M. ^{[1
]}

Esquivias, Jorge ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 01期

基金：

美国国家卫生研究院;

关键词：

asymmetric catalysis; enantioselectivity; ketones; nickel; zinc; SECONDARY ALKYL-HALIDES; ARYLATION; NICKEL; KETONES; PALLADIUM; ESTERS;

D O I：

10.1002/anie.200804888

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Nickel box: The first catalytic asymmetric method for cross-coupling arylzinc reagents with α-bromoketones has been developed (see scheme). This stereoconvergent carbon-carbon bond-forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：154 / 156

页数：3

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