Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: A meta-analysis

被引:82
作者
Weston, A [1 ]
Godbold, JH [1 ]
机构
[1] MT SINAI MED CTR,ENVIRONM HLTH SCI CTR,NEW YORK,NY 10029
关键词
polymorphisms; breast cancer; lung cancer; oncogene; H-ras-1; tumor suppressor gene; p53; susceptibility; Caucasians; African Americans; minorities;
D O I
10.2307/3433304
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Certain polymorphic variants of H-ras-l and p53 have been investigated for an association between inheritance and cancer risk. The results of a metaanalysis, which reviews studies of H-ras-1 rare alleles and p53 codon 72 allelic Variants in breast and lung cancer, are presented. The data constituted evidence for elevated risk of both breast and lung cancer with inheritance of rare H-ras-1 alleles. Calculated population attributable risks are 0.092 and 0.037 for breast and lung cancer, respectively. The frequency of the rare H-ras-l alleles was observed to be greater in African Americans than in Caucasians, and a specific allele (A3.5) that is common in African Americans was found only at low frequency in Caucasians. For p53 a consensus has yet to be reached. Lung cancer studies conducted in Caucasian and African-American populations have found no evidence of risk associated with the proline variant of codon 72. Two similar studies conducted in Japanese populations suggested an association between p53 genotype distribution and lung cancer risk. However, one implicates the proline allele but the other implicates the arginine allele. The frequency of the proline variant is significantly dependent on race. Frequencies. have been reported for control populations of Japanese (0.347 and 0.401), Caucasian (0.295, 0.284, and 0.214), African American (0.628 and 0.527), and Mexican American (0.263).
引用
收藏
页码:919 / 926
页数:8
相关论文
共 81 条
[1]  
AHUJA HG, 1990, ONCOGENE, V5, P1409
[2]   CODON-72 POLYMORPHISM OF THE TP53 GENE [J].
ARA, S ;
LEE, PSY ;
HANSEN, MF ;
SAYA, H .
NUCLEIC ACIDS RESEARCH, 1990, 18 (16) :4961-4961
[3]  
ATLMAN DG, 1991, PRACTICAL STAT MED R, P259
[4]   CHROMOSOME-17 DELETIONS AND P53 GENE-MUTATIONS IN COLORECTAL CARCINOMAS [J].
BAKER, SJ ;
FEARON, ER ;
NIGRO, JM ;
HAMILTON, SR ;
PREISINGER, AC ;
JESSUP, JM ;
VANTUINEN, P ;
LEDBETTER, DH ;
BARKER, DF ;
NAKAMURA, Y ;
WHITE, R ;
VOGELSTEIN, B .
SCIENCE, 1989, 244 (4901) :217-221
[5]   POLYMORPHISM OF THE C-HA-RAS-1 PROTO-ONCOGENE IN SPORADIC AND FAMILIAL BREAST-CANCER [J].
BARKARDOTTIR, RB ;
JOHANNSSON, OT ;
ARASON, A ;
GUDNASON, V ;
EGILSSON, V .
INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (02) :251-255
[6]   P53 POLYMORPHISMS AND HAPLOTYPES IN LUNG-CANCER [J].
BIRGANDER, R ;
SJALANDER, A ;
RANNUG, A ;
ALEXANDRIE, AK ;
SUNDBERG, MI ;
SEIDEGARD, J ;
TORNLING, G ;
BECKMAN, G ;
BECKMAN, L .
CARCINOGENESIS, 1995, 16 (09) :2233-2236
[7]  
BRESLOW NE, 1980, IARC SCI PUBL, V32, P182
[8]  
CARBONE D, 1991, ONCOGENE, V6, P1691
[9]   MUTATIONS IN THE BRCA1 GENE IN FAMILIES WITH EARLY-ONSET BREAST AND OVARIAN-CANCER [J].
CASTILLA, LH ;
COUCH, FJ ;
ERDOS, MR ;
HOSKINS, KF ;
CALZONE, K ;
GARBER, JE ;
BOYD, J ;
LUBIN, MB ;
DESHANO, ML ;
BRODY, LC ;
COLLINS, FS ;
WEBER, BL .
NATURE GENETICS, 1994, 8 (04) :387-391
[10]   EXPRESSION OF RECESSIVE ALLELES BY CHROMOSOMAL MECHANISMS IN RETINOBLASTOMA [J].
CAVENEE, WK ;
DRYJA, TP ;
PHILLIPS, RA ;
BENEDICT, WF ;
GODBOUT, R ;
GALLIE, BL ;
MURPHREE, AL ;
STRONG, LC ;
WHITE, RL .
NATURE, 1983, 305 (5937) :779-784